The road to the Final Four is already underway with the First Round action in the 2025 NCAA Tournament set to get underway this week. March Madness will get started in earnest on Thursday when the first round tips off across the country.

Good luck trying to predict what will happen during the 2025 NCAA Tournament. There are several talented teams capable of making deep runs through this year's bracket. Duke (ACC), Houston (Big 12), Michigan State (Big Ten) and St.

The top betting favorites as the tournament begins: Florida and Duke are listed as co-favorites (+325), according to BetMGM Sportsbook. Auburn (+425) and Houston (+600) are next. The Sweet 16 from March 27 to 30 will put games in Newark, New Jersey (East Regional), Atlanta (South), Indianapolis (Midwest) and San Francisco (West).