From the Human Genome Project to large-scale initiatives like the UK Biobank and The Cancer Genome Atlas (TCGA), the recent ...

The epithelial–mesenchymal transition (EMT) is a source of cancer cell plasticity and tumour heterogeneity, and is ...

For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

Watching mainstream science in America under attack by the US federal and many state governments, most scientists and health ...

Recent studies show that senescent cells accumulate several species of cytosolic DNAs, including mitochondrial DNA (mtDNA), cytoplasmic chromatin fragments (CCFs), and retrotransposable element cDNAs, ...

Dysfunctional mitochondria are a hallmark of T cell ageing and contribute to organismal ageing. This arises from the accumulation of reactive oxygen species (ROS), impaired mitoch ...

imageimageLymphatic vasculature varies widely in structure and function across species, limiting the translatability of lymphatic development studies in animal models to human lymphatic disease. This ...

imageimageMultiple inter- and intra-molecular interfaces stabilise the overall three-dimensional architecture of the Mis18 complex and ensure centromere localisation and function of the CENP-A loading ...

Mitochondrial complex I deficiency is associated with a wide range of clinical presentations, including Leigh syndrome. Its genetic causes are heterogeneous, with poor genotype–phenotype correlation.

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Watching mainstream science in America under ...

The compartmentalization of processes and machineries into organelles is a fundamental concept in the biology of eukaryotic cells. Classic organelles, such as mitochondria or the endoplasmic reticulum ...

External glucose stimulates transcription of several genes including ptsG encoding IICB Glc, a membrane component of the phosphotransferase system (PTS), by relieving the negative regulation of a ...